Technology Platform

Dragon has developed a proprietary DNA vector technology platform that can be used to construct a wide range of therapeutic protein cell lines. Our vectors incorporate a number of distinguishing features that allow for the development of cell lines capable of producing premium quality proteins at exceptionally high yields and low per unit production costs.

Our vector technology platform has been successfully applied to the development and commercial scale-up of our high yield Chinese Hamster Ovary (CHO) cell line for EPO. Having proven our technology with the commercial production of EPO, we are now applying it to the development of the generic drugs in our product pipeline as well as to our novel drug discovery candidates.

What Is Protein Expression?

Recombinant (or genetically engineered) protein expression systems are used to produce large quantities of highly purified human proteins for clinical use. The yield of purified protein that a commercial production system is capable of producing is largely determined by the quality of the cell line used.

A cell line is essentially a genetically engineered population of identical cells which grow indefinitely in culture and which are capable of reproducing (or expressing) a particular type of gene or protein. When introduced into an industrial scale fermentation system, the cell line is induced to produce its specific gene or protein in large quantities.

A key determinant of cell line quality is the sophistication of the vector used to develop the cell line. A vector is a circular fragment of DNA that forms the basis of the cell line development process. By combining itself with DNA from the gene to be expressed by the cell line, the vector serves primarily as the carrier of this gene into the “host cells” which are used to clone (or reproduce) that gene. The efficiency with which the vector performs its “carrier” and related functions determines to a great extent the production capacity of the cell line.

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Dragon Pharmaceuticals Technology