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$10 Million Private Placement Closed

News

The Company is pleased to announce the completion of its recent private placement of 4,258,000 units (the “Units”) at a price of $2.50 per unit for gross proceeds of $10,645,000. Each Unit consists of one common share and one non-transferable share purchase warrant (the “Warrant”). Each Warrant entitles the holder to purchase one common share at a price of $2.50 for a period of one year.

One of the significant placees is the Chow Tai Fook Group, the parent company of the New World Development Company Limited, one of the largest business conglomerates in Hong Kong. New World is a significant player in real estate, infrastructure projects, strategic investments, hotel management, telecommunications, and public transportation. Mr. Cheng Yu-Tung, the Chairman of the Chow Tai Fook Group also serves as Chairman of New World, which is one of the largest shareholders in China.com. Mr. Cheng also serves as a Director of several large Hong Kong companies including Hang Seng Bank Limited.

Dragon Pharmaceuticals, the largest EPO producer in China, is currently a leading biotech company focusing on the research, development, production, and marketing of biodrugs throughout China.

The foregoing includes forward looking statements and readers should not place undue reliance on such forward looking statements, which only reflect the view of management as of the date hereof. The Company does not undertake the obligation to publicly revise these forward-looking statements to reflect subsequent events or circumstances.

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EPO Commercial Production Achieved

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Dragon Pharmaceuticals Inc. is very pleased to announce that a new vector technology has been successfully applied to its EPO production plant at Nanjing Huaxin, China. The yield of the improved EPO cell line has reached 45 mg per liter, well above the Company’s initial expectation.

Optimal annual EPO production from each of the bioreactors is estimated to be over one million doses. With this major technological breakthrough, Huaxin’s annual EPO production capacity can be increased up to five million doses and the direct production cost is being reduced dramatically.

EPO sales in China have increased substantially since the expansion of Huaxin’s marketing network in China. Several high-profile marketing executives were added to Huaxin’s sales team as previously announced.

Huaxin sold approximately 27,000 doses of EPO in China in November. Dragon is working toward establishing a strong marketing team to distribute its EPO produced at Huaxin plant into the international markets. A business to business web site for the marketing of EPO on the internet is currently being investigated to potentially sell Dragon’s EPO to the international market.

The management of the Company is very encouraged by the above major corporate development, which proves the technological platform developed by the Company in China. The Company has achieved the objectives of the first phase of its business plan in a short period of time.

Dragon Pharmaceuticals, the largest EPO producer in China, is currently a leading biotech company focusing on the research, development, production, and marketing of biodrugs throughout China.

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New Directors Appointed

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The Company is pleased to announce that Mr. Philip Yuen Pak Yiu and Dr. Yiu Kwong Sun have been appointed to the Board of Directors.

Mr. Yuen has been a legal practitioner in Hong Kong since graduating from law school in London, England in 1961. In 1965, he established the law firm Yung, Yu, Yuen and Co. and is now the principal partner of the firm. Mr. Yuen has over 30 years experience in the legal field and has been a director of several large listed companies in various sectors. He is a director of the Association of China-appointed Attesting Officers Limited in Hong Kong, a standing committee member of the Chinese General Chamber of Commerce of Hong Kong, a member of the National Committee of the Chinese People Political Consultative Conference and an arbitrator of the China International Economic and Trade Arbitration Commission.

Dr. Sun graduated from the University of Hong Kong Faculty of Medicine in 1967. He is a Founding Fellow of the Hong Kong College of Family Physicians and a Fellow of the Hong Kong Academy of Medicine. He is the Chairman of the Dr. Sun Medical Centre Limited which has been operating a network of medical centres in Hong Kong and China for the past 20 years. He is also the Administration Partner of United Medical Practice, which manages a large network of medical facilities throughout Hong Kong and Macau. Dr. Sun has been a member of the Dr. Cheng Yu Fellowship Committee of Management of the University of Hong Kong Faculty of Medicine since 1997.

The Company also wishes to announce that Mr. Shaun Maskerine has resigned as a Director of the Company to allow for the appointment of new directors. The Board wishes to thank Mr. Maskerine for his contributions to the management of the Company since its inception. Mr. Maskerine will continue to act as Corporate Secretary and Treasurer. The Company is very pleased to have Mr. Yuen and Dr. Sun on its Board of Directors. Each brings valuable experience and expertise encompassing both the medical and legal fields and Asian markets.

Further to the news release dated November 10, 1999 the Company is pleased to announce that preparations for commercial production with its high yield EPO cell line are proceeding on schedule. The Company will host a visit to its Nanjing production plant for a number of fund managers, analysts, and newsletter writers at the end of November.

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Progress Report on Commercial Production

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Dragon Pharmaceutical Inc.  is pleased to announce that Nanjing Huaxin (“Huaxin”) has purchased new bioreactors and that the preparations for commercial production with its high yield EPO cell line are proceeding well. Huaxin is currently working toward increasing the annual EPO production capacity up to a level of 5 million doses while significantly reducing the direct production cost.

The Chinese Medical Association (¡§CMA¡¨), at its September meeting, decided in principle to endorse Huaxin’s EPO as one of the “Recommended Medicines of the CMA”. After final endorsement, Huaxin will be permitted to print the name of the CMA on all packaging and prescription booklets. CMA only endorses the highest quality pharmaceutical products in China. The sales and acceptance of Huaxin¡¦s EPO will be positively affected by the endorsement.

The Company is also pleased to announce that Huaxin’s marketing network has been expanded considerably. Mr. Minghu Luo, the former head of marketing at the largest biotech company in China and a subsidiary of San Francisco based Hambrecht and Quist Investment Corp., was appointed as Huaxin’s Vice President Marketing. The expanded marketing network now covers all major metropolitan areas of China and Huaxin is now the largest EPO provider for several key cities such as Beijing. Sales of Huaxin’s EPO have increased significantly since the implementation of the new marketing network.

In addition, Huaxin has appointed a Marketing Manager and an Associate Marketing Manager. Both held previous appointments as marketing executives at the Chinese subsidiaries of several pharmaceutical companies including Bristol-Meyers Squibb, Merck, and SmithKline Beecham.

Dragon Pharmaceuticals is a biopharmaceutical company with the vision to become a leading biotechnology company in China through research, development, production, and marketing of bio-drugs. To further its goal, the Company acquired a 75% interest in Nanjing Huaxin Biotech Ltd. in Nanjing, China.

The foregoing includes forward looking statements and readers should not place undue reliance on such forward looking statements, which only reflect the view of management as of the date hereof. The Company does not undertake the obligation to publicly revise these forward looking statements to reflect subsequent events or circumstances.

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Dragon Closes Acquisition of Nanjing Huaxin Biotech Ltd

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Dragon Pharmaceutical Inc. is pleased to announce that it has completed the acquisition of Nanjing Huaxin Biotech Ltd. (“Huaxin”) in Nanjing City, China as referred to in the previous news release dated July 7, 1999. The closing of this major transaction was marked by the issuance of a new business license by the Chinese government.

The acquisition makes Dragon Pharmaceuticals the largest producer of Erythropoietin (“EPO”) in China. The Company is now proceeding to increase production and sales of EPO by improving the technology at Huaxin. The Company has also formed a strategic alliance and partnership with Nanjing Medical (Group) Ltd., one of the largest pharmaceutical enterprises in China with extensive experience and expertise in the marketing and distribution of pharmaceutical products in China.

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Dragon Received Independent Confirmation of High Yield Erythropoietin (“EPO”) Cell Line

News

Dragon Pharmaceutical Inc. is pleased to announce that it has received the yield results of an independent test of the EPO cell line constructed by the Company’s Chinese subsidiary using CHO (Chinese Hamster Ovary) cells. The EPO cell line was tested at the Beijing Institute of Microbiology and Epidemiology, an independent lab.

The yield of the EPO cell line was 37 mg/L, calculated by measuring the EPO levels in the harvested media using ELISA. The management of the Company is very encouraged by such a high yield cell line and is confident that the Company’s Chinese subsidiary can produce EPO at much higher yields and at much lower costs than other Chinese EPO producers.

Dragon Pharmaceuticals is the largest producer of EPO in China and plans to apply its vector technology to other biodrug production. The Company has formed a strategic alliance and partnership with Nanjing Medical (Group) Ltd., one of the largest pharmaceutical enterprises in China with extensive experience and expertise in the marketing and distribution of pharmaceutical products in China.

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Acquisition of the Largest Erythropoietin (“EPO”) Producer in China

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Dragon Pharmaceutical Inc. is pleased to announce that its subsidiary, Sanhe Kailong Biopharmaceutical Co., Ltd. (“Kailong”), has entered into an agreement to acquire a 75% interest in Nanjing Huaxin Biopharmaceutical Ltd. (“Huaxin”) of China. This strategic agreement provides Dragon with both the drug license and production permit for the manufacture and marketing of EPO in China.

Kailong will contribute a new vector technology to Huaxin that will allow Huaxin to produce EPO at lower costs and with significantly increased production. Huaxin was the first company to receive an EPO drug license from the Ministry of Health and the first to realize commercial production of the drug in China. It now produces approximately 500,000 doses of EPO, making it the largest domestic producer.

Huaxin has a group of high-tech professional employees, advanced equipment and facilities for biotech research, production and testing, and sales offices in 16 major cities in China. As part of the joint venture agreement, the Company has formed a strategic alliance and partnership with Nanjing Medical (Group) Ltd. (“NMC”). NMC is a Shanghai Stock Exchange-listed company and is one of the largest pharmaceutical enterprises in China. NMC brings extensive experience and expertise in the marketing and distribution of pharmaceutical products in China to the partnership.

The forgoing includes forward looking statements and readers should not place undue reliance on such forward looking statements, which only reflect the view of management as of the date hereof. The Company does not undertake the obligation to publicly revise these forward looking statements to reflect subsequent events or circumstances.

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Dragon Pharmaceuticals Announces Completion of Private Placement

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Dragon Pharmaceuticals Inc. is pleased to announce the completion of the private placement of 2,000,000 common shares at US$0.50 per share. The proceeds will be used to fund the on-going development of the Company’s biotech projects in China.

The working capital of the Company currently stands at approximately US$1.4 million. The Company has invested approximately US$550,000 to date on drug licenses and other assets in China.

At a Board of Directors Meeting held on December 16, 1998, the Board appointed Dr. Longbin Liu as President and Mr. Shaun Maskerine as Secretary of the Company.

Dragon Pharmaceuticals Inc. is a biopharmaceutical company with the vision to become a leading biotechnology company in China through research, development, production, and marketing of previously commercialized bio-drugs.

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Thrombopoietin

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Dragon is developing an engineered version of the naturally occurring human protein thrombopoietin, TPO. This protein is produced mainly by the liver and stimulates the production of blood platelets and bone marrow platelet progenitor (!!±pre-platelet!!L) cells. Platelets are critical to blood clotting and wound healing, and are often diminished in patients receiving cancer chemotherapy, or in those with liver or other relevant diseases, causing thrombocytopenia. This condition can result in uncontrolled bleeding or bruising and is currently treated by high-cost blood transfusions.

The introduction of effective and potent platelet stimulating drugs will greatly improve the treatment of thrombocytopenia and could give rise to a market worth hundreds of millions of dollars. Such products may also increase platelet levels prior to blood donation in normal donors, or in surgery patients whose own blood is used for post-surgical transfusion.

TPO products are under development. Phase I/II randomized, placebo-controlled clinical trials have shown that they increase platelet counts when used prior to or subsequent to chemotherapy. They are also generally well tolerated. Dragon!|s TPO has been tested in animals and is now ready to enter phase I clinical trials in cancer patients. Our first regulatory approvals for this product are expected in 2005.

Dragon has developed a novel system for manufacturing TPO, using Pichia yeast. We expect this technology to produce better yields of TPO than other available production systems, resulting in lower unit costs.

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Human Insulin

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Dragon is developing an engineered version of insulin, a naturally occurring hormone produced by the pancreas. Insulin is critical for regulating the level of glucose in the blood and, since glucose is the primary energy source for the body, is essential for normal metabolism. A defect in insulin production, or an abnormal response to insulin, leads to high glucose concentrations and diabetes. Diabetes takes two major forms: insulin dependent diabetes mellitus (IDDM or Type 1), an autoimmune disease; and non-insulin dependent diabetes mellitus (NIDDM or Type 2), a far more common condition associated with an affluent lifestyle.

Approximately 135 million people worldwide have diabetes, 10% of whom have Type 1 disease. There is no cure for either type of the condition, and insulin injections to regulate blood glucose are required by all Type 1 and approximately 20% of Type 2 patients to permit a near normal lifestyle. The injectable human insulin market was developed by two major pharmaceutical companies, Eli Lilly and Novo Nordisk, and is currently worth $2.76 billion. This market continues to grow as the number of patients with diabetes, particularly Type 2 disease, reaches epidemic proportions.

Dragon has developed a proprietary process for the production of insulin, based on our Pichia yeast cell culturing technology . We believe that this process will result in greater yields and lower production costs than insulin produced by current manufacturers. Preclinical studies with our product should be completed by the end of 2002 and clinical studies are expected to commence in mid-2003. We anticipate first launch of Dragon insulin by the end of 2004.

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